Resolvin D1 reverses reactivity and Ca sensitivity induced by ET-1, TNF- , and IL-6 in the human pulmonary artery
نویسندگان
چکیده
Roddy Hiram, Edmond Rizcallah, Chantal Sirois, Marco Sirois, Caroline Morin, Samuel Fortin, and Eric Rousseau Department of Physiology and Biophysics, Université de Sherbrooke, Sherbrooke, Quebec, Canada; Department of Pathology, Université de Sherbrooke, Sherbrooke, Quebec, Canada; Service of Thoracic Surgery Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada; and SCF Pharma, Ste-Luce, Quebec, Canada
منابع مشابه
TRANSLATIONAL PHYSIOLOGY Resolvin D1 reverses reactivity and Ca sensitivity induced by ET-1, TNF- , and IL-6 in the human pulmonary artery
Roddy Hiram, Edmond Rizcallah, Chantal Sirois, Marco Sirois, Caroline Morin, Samuel Fortin, and Eric Rousseau Department of Physiology and Biophysics, Université de Sherbrooke, Sherbrooke, Quebec, Canada; Department of Pathology, Université de Sherbrooke, Sherbrooke, Quebec, Canada; Service of Thoracic Surgery Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec...
متن کاملResolvin D1 reverses reactivity and Ca2+ sensitivity induced by ET-1, TNF-α, and IL-6 in the human pulmonary artery.
Pulmonary hypertension (PH) is a rare and progressive disease characterized by an inflammatory status and vessel wall remodeling, resulting in increased pulmonary artery resistance. During the last decade, treatments have been proposed; most of them target the endothelial pathways that stimulate smooth muscle cell relaxation. However, PH remains associated with significant morbidity. We hypothe...
متن کاملCALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies Resolvin E1 normalizes contractility, Ca sensitivity and smooth muscle cell migration rate in TNF- - and IL-6-pretreated human pulmonary arteries
Roddy Hiram, Edmond Rizcallah, Sofia Marouan, Chantal Sirois, Marco Sirois, Caroline Morin, Samuel Fortin, and Eric Rousseau Department of Pharmacology and Physiology, Université de Sherbrooke, Sherbrooke, Quebec, Canada; Department of Obstetrics-Gynecology, Université de Sherbrooke, Sherbrooke, Quebec, Canada; Department of Pathology, Université de Sherbrooke, Sherbrooke, Quebec, Canada; Servi...
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BACKGROUND We investigated the influence of Resolvin D1 (RvD1) on the inflammatory response in PC12 cells (a cell model of Parkinson disease, PD). MATERIAL AND METHODS 4 mmol/L 1-methyl-4-phenylpyridinium ion (Mpp+) was used in PC12 cells for an in vitro PD model. 3-(4,5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide (MTT) assay was used to explore PC12 cell viability. Western blot...
متن کاملResolvin D1 and E1 alleviate the progress of hepatitis toward liver cancer in long-term concanavalin A-induced mice through inhibition of NF-κB activity.
Resolvins, an endogenous lipid mediator derived from eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) of fish oil, has been reported to have anti-inflammatory and antitumor effect in various pathogenic processes. However, there are no studies about the effects of resolvin D1 and E1 on concanavalin A-induced hepatitis. Hence, the present study is to illustrate whether resolvin D1 and E1...
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